A happy family is separated and the rest of the story is about how they strive to be reunited.
Two loves are separated and the rest of the story tells about their struggle to reunite.
A dog has wandered away from his family and the rest of the story describes their frantic search for him and his longing to reunite with them.
A selfish sinner runs away from Providence, and the rest of the story is about how he is eventually restored and reunited with his conscience, with his fellow human beings, and with love.
How many stories really are about breaking something apart and subsequently putting those pieces back where they belong? How does the plot build? What does the reader really want to know? How they will get back together? Whether or not they will get back together? Build on that. Stretch it. Let them almost make it and let them fail. Get your audience biting their figurative fingernails.
Now get to it. Write on!